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Int J Drug Res Clin. 2023;1: e12.
doi: 10.34172/ijdrc.2023.e12
  Abstract View: 484
  PDF Download: 271

Original Article

The Effect of Short-term Methylprednisolone on Clinical Outcome and Lung CT Scan in Severe COVID-19: In-hospital and Six Weeks Later Follow-up

Maryam Sadat Mirenayat 1,2 ORCID logo, Somaye Sadeghi 3,4 ORCID logo, Atefeh Fakharian 1,2 ORCID logo, Reyhaneh Zahiri 1,2 ORCID logo, Syed Bashir Mirtajani 5 ORCID logo, Zahra Amraei 6 ORCID logo, Maryam Vasheghani 1* ORCID logo

1 Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Pulmonary Rehabilitation Research Center (PRRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Infectious Disease and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Acquired Immunodeficiency Research Center, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
5 Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Faculty of Sport Sciences and Health, University of Shahid Beheshti, Tehran, Iran
*Corresponding Author: Maryam Vasheghani,, Email: mvasheghani9@gmail.com

Abstract

Background: The severe coronavirus disease 2019 (COVID-19) induces widespread inflammatory responses that are attempted to be managed by the administration of anti-inflammatory drugs, along with antiviral drugs and respiratory support. This clinical trial study investigated the effect of short-term and low-dose methylprednisolone on the clinical outcome and radiological improvement of admitted patients with severe COVID-19.

Methods: In this randomized clinical trial, two strains of patients with severe pneumonia of COVID-19 were evaluated before and after the use of corticosteroids. Inclusion criteria were age over 18 years, definitive case of COVID-19 based on positive reverse transcription polymerase chain reaction (RT-PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), and arterial oxygen saturation (SaO2 )<93%; furthermore, at least 7 days and 5 days should be passed since the onset of symptoms and antiviral treatment, respectively. Exclusion criteria were similar to contraindications to the administration of methylprednisolone for short-term injections and pregnancy. Patients received intravenous methylprednisolone succinate (1-1.75 mg/kg/day) for 5 days in addition to treatment based on the World Health Organization (WHO) approved protocol for COVID-19. Finally, demographic characteristics, dyspnea, peripheral oxygen saturation (SpO2), number of lymphocytes, and computed tomography (CT) scan of the patient’s chest before and after taking corticosteroids were evaluated.

Results: The average oxygen saturation of patients increased significantly after taking methylprednisolone succinate (P<0.001). Moreover, dyspnea and pulmonary insufficiency in CT scans improved significantly (P<0.001), and among hematological parameters, only lymphocytes increased significantly (P=0.01). Furthermore, methylprednisolone succinate use had no effect on mortality and length of hospitalization.

Conclusion: Methylprednisolone succinate use during the treatment period of COVID-19 improves clinical conditions, CT scan findings, and hematological parameters affected by inflammation, but it does not affect the mortality and length of hospitalization of patients.


Please cite this article as follows: Mirenayat MS, Sadeghi S, Fakharian A, Zahiri R, Mirtajani SB, Amraei Z, et al. The Effect of short-term methylprednisolone on clinical outcome and lung CT scan in severe COVID-19: In-hospital and six weeks later follow-up. Int J Drug Res Clin. 2023;1: e12. doi: 10.34172/ijdrc.2023.e12
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Submitted: 13 Mar 2023
Revision: 10 Apr 2023
Accepted: 11 Apr 2023
ePublished: 31 Jul 2023
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