Tabriz Valiasr International Hospital Publication International Journal of Drug Research in Clinics 2980-9835 3 1 2025 01 12 Exploring Therapeutic Potentials of Photobiomodulation Therapy (PBMT) In Urogenital Disorders: A Comprehensive Review e14 e14 10.34172/ijdrc.2025.e14 EN Fateme Tahmasbi https://orcid.org/0000-0002-0652-7693 Farzin Soleimanzadeh https://orcid.org/0000-0003-2427-8819 Reza Aletaha https://orcid.org/0000-0002-5392-9599 Alireza Rahimi-Mamaghani https://orcid.org/0009-0000-8020-2697 REVIEW 10.34172/ijdrc.2025.e14 2024 08 02 2024 09 28 This comprehensive review aimed to provide an evidence-based overview of the therapeutic potential of photobiomodulation therapy (PBMT) in managing urogenital conditions. A systematic search was conducted in Web of Science, PubMed, Scopus, and Google Scholar using various MeSH terms and keywords, resulting in the identification of 8 preclinical and 14 clinical studies. The findings suggest that PBMT demonstrates promising therapeutic effects in both human studies and animal models by stimulating cellular processes and tissue repair. Although limited by poor penetration with certain devices, PBMT was found to prevent bladder cancer development and improve renal oxidative stress markers in diabetic rats. In humans, PBMT has been shown to improve sperm parameters, manage chronic pelvic diseases, alleviate pain, and enhance pelvic floor muscle strength. These findings indicate that PBMT has broad therapeutic potential for pelvic and urogenital disorders, warranting further research to clarify its mechanisms and long-term efficacy.