Tabriz Valiasr International Hospital Publication International Journal of Drug Research in Clinics 2980-9835 3 1 2025 01 12 Preoperative Nutritional Status as a Determinant of Mortality in Patients with Gastric Cancer Undergoing Gastrectomy: A Prospective Study e3 e3 10.34172/ijdrc.2025.e3 EN Zeinab Nikniaz Mohammad Hossein Somi Shahnaz Naghashi Journal Article 10.34172/ijdrc.2025.e3 2024 07 29 2024 09 29 Background: This study aimed to determine the prognostic factors related to three-year survival in patients with gastric cancer (GC) undergoing gastrectomy. Methods: A total of 124 patients with GC undergoing gastrectomy were enrolled in this prospective study from September 2016 to October 2019. The three-year survival rate was assessed. Clinical records, the socioeconomic status (SES) questionnaire, and the Patient-Generated Subjective Global Assessment (PG-SGA) were used to evaluate tumor-related information, SES, and nutritional status, respectively. The Cox proportional hazard model was used to identify determinants of mortality. Results: During the follow-up period, 29.03% of the patients died. Significant differences were observed between deceased and non-deceased patients regarding PG-SGA scores (P=0.01). The results of the univariate Cox regression models indicated that age (OR: 1.02, 95% CI: 1.03-1.04), tumor–node–metastasis (TNM) stage 3 (OR: 13.22, 95% CI: 4.30-42.26), poor pre-surgery nutritional status (OR: 2.57, 95% CI: 1.67-3.97), and a medium level of physical activity (PA) (OR: 0.62, 95% CI: 0.4-0.95) are the significant determinant of three-year mortality in patients with GC undergoing gastrectomy. In the multivariate model, only TNM stage 3 and poor nutritional status remained significant. Conclusion: Based on the results, it is recommended that all patients with GC undergo a nutritional status assessments before gastrectomy, with suitable clinical management tailored accordingly.