Tabriz Valiasr International Hospital Publication International Journal of Drug Research in Clinics 2980-9835 2 1 2024 02 21 Effect of Saffron and Melissa officinalis L. Supplementation on Glycemic Parameters and Lipid Profile in Patients with Type 2 Diabetes Mellitus: A Double-Blind Clinical Trial e21 e21 10.34172/ijdrc.2024.e21 EN Behnam Sadighi https://orcid.org/0009-0004-5624-022X Reza Yarani Somaiyeh Taheri-Targhi Sarvin Sanaie Seyed Kazem Shakouri Majid Mobasseri Zahra Yousefi https://orcid.org/0000-0002-8708-6358 Mostafa Araj-Khodaei https://orcid.org/0000-0002-2590-8467 Journal Article 10.34172/ijdrc.2024.e21 2024 07 21 2024 09 13 Background: Diabetes is one of the most common diseases in modern societies. The prevalence of type 2 diabetes mellitus (T2DM) is rising and is expected to reach 440 million people by 2030. Although effective steps have been taken in diabetes treatment using common chemical drugs, these drugs are often followed by numerous side effects, necessitating the search for new medications with natural origin, especially those derived from traditional and complementary medicine. Methods: In this double-blind clinical trial, 90 type 2 diabetic patients were randomly divided into three groups: saffron (30 patients), Melissa officinalis (29 patients), and placebo (28 patients). After obtaining informed written consent from each patient, blood samples were collected from all participants, and the corresponding drug was delivered to each patient. After the participants took the medications for three months, blood samples were taken again to analyze the biochemical parameters. Data were analyzed using SPSS version 24, employing both descriptive and inferential statistics. Results: At the outset of the investigation, no significant differences existed among the three groups regarding the pertinent variables. The results showed that saffron supplement and M. officinalis significantly decreased fasting blood sugar (FBS) (P<0.001), hemoglobin A1C (HbA1c) (P<0.05), triglyceride (P<0.05), and total cholesterol (P<0.001) compared to pre-intervention stage. No significant effects were observed for other parameters. Conclusion: This study demonstrated that lemongrass and saffron extracts significantly affected the control of FBS, HbA1c, triglycerides, and blood cholesterol levels in type 2 diabetes patients, suggesting their administration alongside other treatments.